When the movie opens up with vampires investigating ruins and needing artificial light sources to see, you know you are in trouble.

Blade is set up to murder a non-vamp, and now the FBI wants to take him down.  Mix in a high-tech Scooby Gang from Buffy and you get the "Nightstalkers" who have to help Blade.  Yes, Blade, the guy that killed the Vampire God in Blade, the guy that killed the father of the Ubervamps in Blade II, needs help.  *yawn*

The bad vamps find Dracula and bring him back to the city.  Why Dracula continues to hang out with him, or even cares what they think is explained...oh wait, it isn't.

The required "hot chick" in the movie hunts vampires while listen to an IPOD.  So you are going to hunt the baddest predator in the world, and not use your hearing?  Let's go hunt sharks, blindfolded!  And while I am on that subject, she really isn't that hot, she can't act...really she just plain sucks.  Please go away.  Now, Ryan Reynolds...holy crap.  The dude swallowed Arnold or something.  Where the hell did his shredded body come from?

Lastly Snipes just looks bored and like he is there for the paycheck, which turns out to be mostly true, as he hated the movie.  And I do too.  You probably should too, even if you haven't seen it.